Royal Air Force Typhoon jets have operated alongside France's air force in a joint strike on an subterranean weapons facility in Syrian territory operated by the IS group, according to the British defence ministry.
The facility, identified by surveillance, was assessed as housing weapons and explosive materials, the statement said, and was situated in mountainous terrain just north of the historic site of Palmyra in central Syria.
"Our aircraft employed precision-guided Paveway IV munitions to hit a several approach shafts providing entry to the site... initial indications indicate the target was engaged successfully," the MoD said.
There was no indication of any civilian impact in the strike on Saturday evening and all the aircraft made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - alternatively referred to as Daesh - enforced militant control over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates the UK's leading role, and determination to operate in unison with our partners, to eliminate any re-emergence of Daesh and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary said.
UK warplanes have carried out surveillance missions over Syrian airspace to "forestall any attempted resurgence" of the group following its military defeat at the battle of Baghuz in 2019, the authorities noted.
"I must thank all the members of British forces who took part in this operation for their expertise and their valour," the Defence Secretary added. "They were among thousands of British personnel stationed over Christmas and New Year. This action, to remove dangerous terrorists who endanger our way of life, shows how our armed forces are ready to step up, all year round, keeping Britain secure domestically and influential overseas."
During December, the United States armed forces carried out what it called a "large-scale strike" against Islamic State objectives in the country, after an assault resulted in the deaths of two US troops and a civilian linguist in Palmyra.
The United Nations says Daesh still maintains an estimated 5,000 to 7,000 militants in Syria and Iraq.